Evaluation of anti-cytogenotoxic potential of Atriplex portulacoides crude extract in mice bone marrow.

Document Type : Original Article

Authors

1 Agric. Biotechnology Department, Faculty of Agriculture, Damietta University, Egypt

2 Genetics Department, Faculty of Agriculture, Mansoura University, Egypt

3 Genetics Department, Faculty of Agriculture, Ain shams University, Egypt

Abstract

Medicinal plants are essential to traditional medical systems because they are abundant in biologically active compounds that support the physiological and biochemical functions of living organisms. Among these actions, anti-cytogenotoxic qualities are particularly noteworthy, as they offer protection against cytogenotoxicity caused by unfavorable environmental conditions. Our current study evaluates the anti-cytogenotoxic properties of the crude extract of A. portulacoides by assessing the rates of aberrant mitosis in mice bone marrow. Mice were administered 5 mg/kg body weight of A. portulacoides crude extract three times a week for two weeks before receiving mitomycin C (MMC). A separate group of mice received MMC alone as a positive control. The findings demonstrated that exposure to MMC statistically significantly increased chromosomal abnormalities compared to the control group. While, pre-treatment with A. portulacoides crude extract resulted in a significant reduction in the MMC-induced rate of both structural and numerical chromosomal aberrations and increased the mitotic index. Overall, our results suggest that the A. portulacoides crude extract could be a protective food supplement and a promising agent to reduce the cytogenotoxicity effects that may result from anticancer drugs. However, further study is necessary to confirm these potential benefits.

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Damietta Journal of Agricultural Sciences
Volume 4, Issue 2
July 2025
Pages 116-122

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